Drug Information

Drug General Information
Drug ID
D0X2PQ
Former ID
DIB016647
Drug Name
IX207-887
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Discontinued in Phase 2 [545177]
Company
Sandoz AG
Canonical SMILES
C\1(=C\C(=O)O)/c2c(C(=Cc3c1cccc3)OC)scc2
CAS Number
CAS 98320-39-9
Target and Pathway
Target(s) Interleukin-1 alpha ligand Target Info Modulator [532430]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
Apoptosis
Osteoclast differentiation
Hematopoietic cell lineage
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Prion diseases
Salmonella infection
Pertussis
Leishmaniasis
Tuberculosis
Measles
Influenza A
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Graft-versus-host disease
NetPath Pathway IL5 Signaling Pathway
IL1 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database IL1-mediated signaling events
Validated transcriptional targets of deltaNp63 isoforms
a6b1 and a6b4 Integrin signaling
Reactome Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 signaling
Interleukin-1 processing
WikiPathways SIDS Susceptibility Pathways
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Cytokines and Inflammatory Response
Hypertrophy Model
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Hematopoietic Stem Cell Differentiation
Structural Pathway of Interleukin 1 (IL-1)
Spinal Cord Injury
Allograft Rejection
IL-1 signaling pathway
Interleukin-1 signaling
References
Ref 545177Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002363)
Ref 532430Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62.

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