Drug Information

Drug General Information
Drug ID
D0YL3E
Former ID
DCL000370
Drug Name
GSK159802
Indication Chronic obstructive pulmonary disease; Asthma [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Discontinued in Phase 2 [548082]
Company
GSK
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [550963]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548082Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021784)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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