Drug Information

Drug General Information
Drug ID
D0ZM5E
Former ID
DIB014841
Drug Name
VCL-1M01
Synonyms
VCL-1M01; VCL-IM01; EPT (plasmid DNA), Vical; IL-2/EP; MedPulser, cancer (plasmid DNA), Vical; Plasmid DNA (transdermal, EPT), Vical; IL-2 gene therapy (plasmid, transdermal, melanoma); IL-2 gene therapy (pVCL-1102 plasmid DNA vector, melanoma), Vical; IL-2 gene therapy (plasmid, transdermal, melanoma), Vical
Indication Melanoma [ICD9: 172; ICD10:C43] Phase 1 [521725]
Company
Vical Inc
Target and Pathway
Target(s) Interleukin-2 Target Info Modulator [533711]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Chagas disease (American trypanosomiasis)
Measles
HTLV-I infection
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejection
Graft-versus-host disease
NetPath Pathway IL-7 Signaling Pathway
TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
SHP2 signaling
Regulation of Telomerase
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
AP-1 transcription factor network
IL23-mediated signaling events
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways Cytokines and Inflammatory Response
IL-2 Signaling Pathway
Inflammatory Response Pathway
Aryl Hydrocarbon Receptor Pathway
Interleukin-2 signaling
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Corticotropin-releasing hormone
Allograft Rejection
Arylhydrocarbon receptor (AhR) signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Folate Metabolism
IL-5 Signaling Pathway
References
Ref 521725ClinicalTrials.gov (NCT00223899) A Trial to Evaluate the Safety of Intratumoral VCL-IM01 Followed by Electroporation in Metastatic Melanoma. U.S. National Institutes of Health.
Ref 533711Interleukin-2 gene therapy in a patient with glioblastoma. Gene Ther. 1995 Mar;2(2):164-7.

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