Resistance mutation info of target

Target General Information
Target ID T53489
Target Name Parasitic Cytochrome b (MT-CYB) Target Info
Gene Name MT-CYB
Species Plasmodium falciparum
Uniprot ID CYB_PLAFA
Sequence MNFYSINLVKAHLINYPCPLNINFLWNYGFLLGIIFFIQIITGVFLASRYTPDVSYAYYS
IQHILRELWSGWCFRYMHATGASLVFLLTYLHILRGLNYSYMYLPLSWISGLILFMIFIV
TAFVGYVLPWGQMSYWGATVITNLLSSIPVAVIWICGGYTVSDPTIKRFFVLHFILPFIG
LCIVFIHIFFLHLHGSTNPLGYDTALKIPFYPNLLSLDVKGFNNVIILFLIQSLFGIIPL
SHPDNAIVVNTYVTPSQIVPEWYFLPFYAMLKTVPSKPAGLVIVLLSLQLLFLLAEQRSL
TTIIQFKMIFGARDYSVPIIWFMCAFYALLWIGCQLPQDIFILYGRLFIVLFFCSGLFVL
VHYRRTHYDYSSQANI [Plasmodium falciparum]
Drug Resistance Mutation and Corresponding Drugs
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Mutation Info Missense: Y268S
Drugs
Drug Name Atovaquone Drug Info [556034]
Targeted Disease Plasmodium Falciparum Malaria
Reference
Ref 556034Understanding the mechanism of atovaquone drug resistance in Plasmodium falciparum cytochrome b mutation Y268S using computational methods. PLoS One. 2014 Oct 15;9(10):e110041. doi: 10.1371/journal.pone.0110041. eCollection 2014.

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