Target Information

Target General Infomation
Target ID
T06397
Former ID
TTDR00610
Target Name
Methionine gamma-lyase
Gene Name
mdeA
Synonyms
L-methioninase; mdeA
Target Type
Research
BioChemical Class
Carbon-sulfur lyases
UniProt ID
P13254
EC Number
EC 4.4.1.11
Sequence
MHGSNKLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYS
RISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAF
LHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHG
ATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLK
DMTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQY
TLARQQMSQPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYT
PEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKASA
Inhibitor N'-Pyridoxyl-Lysine-5'-Monophosphate Drug Info [551393]
Trifluoromethionine Drug Info [536590]
References
Ref 536590Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis. FEBS J. 2008 Feb;275(3):548-60.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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