Drug Information

Drug General Information
Drug ID
D07IHM
Former ID
DNC008992
Drug Name
CEP-6331
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529647]
Formula
C27H26N2O3
Canonical SMILES
CC(C)OC1=CC2=C(C=C1)C3=C4C(=C5C6=CC=CC=C6N(C5=C3CC2)CCO<br />)CNC4=O
InChI
1S/C27H26N2O3/c1-15(2)32-17-8-10-18-16(13-17)7-9-20-23(18)25-21(14-28-27(25)31)24-19-5-3-4-6-22(19)29(11-12-30)26(20)24/h3-6,8,10,13,15,30H,7,9,11-12,14H2,1-2H3,(H,28,31)
InChIKey
HSWWFIPPMAFLPH-UHFFFAOYSA-N
PubChem Compound ID
9823787
Target and Pathway
Target(s) Mitogen-activated protein kinase kinase kinase 11 Target Info Inhibitor [529647]
Mitogen-activated protein kinase kinase kinase 10 Target Info Inhibitor [529647]
Mitogen-activated protein kinase kinase kinase 9 Target Info Inhibitor [529647]
Vascular endothelial growth factor receptor 3 Target Info Inhibitor [529647]
Fyn tyrosine kinase Target Info Inhibitor [529647]
Neurotrophic tyrosine kinase receptor 1 Target Info Inhibitor [529647]
KEGG Pathway MAPK signaling pathway
Non-alcoholic fatty liver disease (NAFLD)hsa04014:Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesionhsa04071:Sphingolipid signaling pathway
Axon guidance
Osteoclast differentiation
Focal adhesion
Adherens junction
Platelet activation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Cholinergic synapse
Prion diseases
Pathogenic Escherichia coli infection
Measles
Viral myocarditishsa04010:MAPK signaling pathway
Endocytosis
Apoptosis
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Central carbon metabolism in cancer
NetPath Pathway TNFalpha Signaling PathwayNetPath_23:TSH Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway CCKR signaling map STP00029:Huntington disease
p38 MAPK pathwayP00007:Axon guidance mediated by semaphorins
Cadherin signaling pathway
Integrin signalling pathway
Parkinson disease
Pathway Interaction Database Reelin signaling pathway
CDC42 signaling events
IFN-gamma pathway
RAC1 signaling pathwayp38_mkk3_6pathway:p38 MAPK signaling pathwayvegf_vegfr_pathway:VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endotheliumfcer1pathway:Fc-epsilon receptor I signaling in mast cells
ErbB4 signaling events
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
Ephrin A reverse signaling
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
Netrin-mediated signaling events
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
Posttranslational regulation of adherens junction stability and dissassembly
amb2 Integrin signaling
EPHA forward signaling
E-cadherin signaling in keratinocytes
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocyte
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-3-mediated signaling events
Ephrin B reverse signaling
Alpha-synuclein signaling
Signaling events mediated by focal adhesion kinasetrkrpathway:Neurotrophic factor-mediated Trk receptor signaling
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome VEGF binds to VEGFR leading to receptor dimerizationR-HSA-114604:GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin interactions
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
CRMPs in Sema3A signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-170968:Frs2-mediated activation
ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activation
WikiPathways Insulin SignalingWP481:Insulin Signaling
p38 MAPK Signaling PathwayWP1919:Signaling by VEGFWP69:TCR Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Kit receptor signaling pathway
IL-3 Signaling Pathway
Ectoderm Differentiation
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
Primary Focal Segmental Glomerulosclerosis FSGS
BDNF signaling pathway
Interleukin-11 Signaling Pathway
B Cell Receptor Signaling Pathway
Pathogenic Escherichia coli infection
TSLP Signaling Pathway
IL-7 Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Platelet Adhesion to exposed collagen
Netrin-1 signaling
Nephrin interactions
NCAM signaling for neurite out-growth
Integrin-mediated Cell Adhesion
GPVI-mediated activation cascade
Costimulation by the CD28 family
Cell surface interactions at the vascular wallWP382:MAPK Signaling Pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membrane
References
Ref 529647J Med Chem. 2008 Sep 25;51(18):5680-9. Epub 2008 Aug 21.Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Ref 529647J Med Chem. 2008 Sep 25;51(18):5680-9. Epub 2008 Aug 21.Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.