Drug Information

Drug General Information
Drug ID
D0Z4HV
Former ID
DNC004095
Drug Name
7-Chloro-3-pyridin-4-yl-quinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533872]
Formula
C14H9ClN2
Canonical SMILES
C1=CC(=CC2=NC=C(C=C21)C3=CC=NC=C3)Cl
InChI
1S/C14H9ClN2/c15-13-2-1-11-7-12(9-17-14(11)8-13)10-3-5-16-6-4-10/h1-9H
InChIKey
WMECTFBVYBAOOF-UHFFFAOYSA-N
PubChem Compound ID
10354294
Target and Pathway
Target(s) Alpha platelet-derived growth factor receptor Target Info Inhibitor [533872]
Beta platelet-derived growth factor receptor Target Info Inhibitor [533872]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Choline metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling networkptp1bpathway:Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling network
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
Hair Follicle Development: Organogenesis (Part 2 of 3)
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Signaling Pathways in Glioblastoma
Signaling by PDGF
AngiogenesisWP51:Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
PDGF Pathway
References
Ref 533872J Med Chem. 1994 Aug 19;37(17):2627-9.5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.
Ref 533872J Med Chem. 1994 Aug 19;37(17):2627-9.5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.

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