Drug Information

Drug General Information
Drug ID
D08RZB
Former ID
DIB019318
Drug Name
compound 2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526872], [527295]
Formula
C17H16ClN5OS
InChI
InChI=1S/C17H16ClN5OS/c1-9-5-4-6-12(18)15(9)23-16(24)13-8-19-17(25-13)22-14-7-10(2)20-11(3)21-14/h4-8H,1-3H3,(H,23,24)(H,19,20,21,22)
InChIKey
WFRLFWGASBLYTC-UHFFFAOYSA-N
PubChem Compound ID
11153014
PubChem Substance ID
16231814, 23348306, 42207809, 46513677, 77024063, 103454583, 129574854, 140208187, 180061391, 227057194, 249565816
Target and Pathway
Target(s) HCK proto-oncogene, Src family tyrosine kinase Target Info Inhibitor [527295]
Fyn tyrosine kinase Target Info Inhibitor [527295]
FGR proto-oncogene, Src family tyrosine kinase Target Info Inhibitor [527295]
BLK proto-oncogene, Src family tyrosine kinase Target Info Inhibitor [527295]
Lck tyrosine kinase Target Info Inhibitor [527295]
Proto-oncogene tyrosine-protein kinase SRC Target Info Inhibitor [527295]
Tyrosine-protein kinase JAK3 Target Info Inhibitor [527295]
KEGG Pathway Sphingolipid signaling pathway
Axon guidance
Osteoclast differentiation
Focal adhesion
Adherens junction
Platelet activation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Cholinergic synapse
Prion diseases
Pathogenic Escherichia coli infection
Measles
Viral myocarditishsa04064:NF-kappa B signaling pathway
HTLV-I infection
Primary immunodeficiencyhsa04012:ErbB signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Endocytosis
VEGF signaling pathway
Tight junction
Gap junction
GABAergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Tuberculosis
Hepatitis B
Viral carcinogenesis
Proteoglycans in cancerhsa04062:Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Epstein-Barr virus infection
Primary immunodeficiency
NetPath Pathway TSH Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Axon guidance mediated by semaphorins
Cadherin signaling pathway
Integrin signalling pathway
Parkinson diseaseP00049:Parkinson disease
T cell activationP00005:Angiogenesis
Parkinson disease
CCKR signaling map STP00036:Interleukin signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
ErbB4 signaling events
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
Ephrin A reverse signaling
Reelin signaling pathway
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
Netrin-mediated signaling events
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
Posttranslational regulation of adherens junction stability and dissassembly
amb2 Integrin signaling
EPHA forward signaling
E-cadherin signaling in keratinocytes
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocyte
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-3-mediated signaling events
Ephrin B reverse signaling
Alpha-synuclein signaling
Signaling events mediated by focal adhesion kinasenfkappabatypicalpathway:Atypical NF-kappaB pathway
IL12-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Alpha-synuclein signalingendothelinpathway:Endothelins
Signaling events mediated by PRL
LPA receptor mediated events
Atypical NF-kappaB pathway
Plasma membrane estrogen receptor signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
S1P3 pathway
EPHB forward signaling
Nectin adhesion pathway
CDC42 signaling events
Signaling events regulated by Ret tyrosine kinase
Arf6 signaling events
Signaling events mediated by TCPTP
FAS (CD95) signaling pathway
Alpha9 beta1 integrin signaling events
EGF receptor (ErbB1) signaling pathway
Regulation of Androgen receptor activity
E-cadherin signaling in the nascent adherens junction
Integrins in angiogenesis
ErbB1 downstream signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
ErbB2/ErbB3 signaling events
Nongenotropic Androgen signaling
Internalization of ErbB1
CXCR3-mediated signaling events
Syndecan-2-mediated signaling events
Class I PI3K signaling events mediated by Akt
Trk receptor signaling mediated by PI3K and PLC-gamma
EPHA2 forward signaling
FGF signaling pathway
Alpha4 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinaseil4_2pathway:IL4-mediated signaling events
CD40/CD40L signaling
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin interactions
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
CRMPs in Sema3A signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-114604:GPVI-mediated activation cascade
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Interleukin-2 signalingR-HSA-114604:GPVI-mediated activation cascade
Interleukin-7 signaling
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
Interleukin receptor SHC signaling
WikiPathways TCR Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Kit receptor signaling pathway
IL-3 Signaling Pathway
Ectoderm Differentiation
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
Primary Focal Segmental Glomerulosclerosis FSGS
BDNF signaling pathway
Interleukin-11 Signaling Pathway
B Cell Receptor Signaling Pathway
Pathogenic Escherichia coli infection
TSLP Signaling Pathway
IL-7 Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Platelet Adhesion to exposed collagen
Netrin-1 signaling
Nephrin interactions
NCAM signaling for neurite out-growth
Integrin-mediated Cell Adhesion
GPVI-mediated activation cascade
Costimulation by the CD28 family
Cell surface interactions at the vascular wallWP61:Notch Signaling Pathway
Inflammatory Response Pathway
TCR signaling
Costimulation by the CD28 familyWP673:ErbB Signaling Pathway
Senescence and Autophagy in Cancer
Notch Signaling Pathway
EPO Receptor Signaling
EGF/EGFR Signaling Pathway
TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Pregnane X Receptor pathway
Aryl Hydrocarbon Receptor Pathway
Nanoparticle-mediated activation of receptor signaling
Polycystic Kidney Disease Pathway
Alpha 6 Beta 4 signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Signaling Pathways in Glioblastoma
Arylhydrocarbon receptor (AhR) signaling pathway
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
RANKL/RANK Signaling Pathway
Angiogenesis
Androgen receptor signaling pathwayWP49:IL-2 Signaling Pathway
IL-4 Signaling Pathway
Interleukin-2 signaling
Interleukin-7 signaling
IL-9 Signaling Pathway
Interleukin-3, 5 and GM-CSF signaling
References
Ref 526872Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett. 2003 Nov 17;13(22):4007-10.
Ref 527295Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6.
Ref 527295Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6.

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