TTD | Drug: D02NNT

Drug General Information
Drug ID	D02NNT
Former ID	DIB019310
Drug Name	compound 1d
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531435]
Formula	C17H15F2N7
InChI	InChI=1S/C17H15F2N7/c1-9-5-15(26-25-9)23-17-13(19)6-11(7-20)16(24-17)22-10(2)14-4-3-12(18)8-21-14/h3-6,8,10H,1-2H3,(H3,22,23,24,25,26)/t10-/m0/s1
InChIKey	HIHOEGPXVVKJPP-JTQLQIEISA-N
PubChem Compound ID	53232451
PubChem Substance ID	124341313, 131272679, 131346662, 180420949, 239809889, 244871390, 249565803
Target and Pathway
Target(s)	muscle, skeletal, receptor tyrosine kinase	Target Info	Inhibitor	[531435]
	Tyrosine-protein kinase JAK2	Target Info	Inhibitor	[531435]
	FGF-3 receptor	Target Info	Inhibitor	[531435]
	Trk receptor	Target Info	Inhibitor	[531435]
	Tyrosine-protein kinase JAK3	Target Info	Inhibitor	[531435]
	Proto-oncogene tyrosine-protein kinase receptor ret	Target Info	Inhibitor	[531435]
KEGG Pathway	Chemokine signaling pathway
	PI3K-Akt signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Jak-STAT signaling pathway
	Cholinergic synapse
	Prolactin signaling pathway
	Adipocytokine signaling pathway
	Leishmaniasis
	Toxoplasmosis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infectionhsa04010:MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Endocytosis
	Regulation of actin cytoskeleton
	Pathways in cancer
	MicroRNAs in cancer
	Bladder cancer
	Central carbon metabolism in cancerhsa04062:Chemokine signaling pathway
	HTLV-I infection
	Epstein-Barr virus infection
	Viral carcinogenesis
	Primary immunodeficiencyhsa04144:Endocytosis
	Thyroid cancer
	Central carbon metabolism in cancer
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interferon-gamma signaling pathway
	JAK/STAT signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	CCKR signaling map STP00021:FGF signaling pathwayP00036:Interleukin signaling pathway
Pathway Interaction Database	Endothelins
	ErbB4 signaling events
	GMCSF-mediated signaling events
	IL4-mediated signaling events
	IL27-mediated signaling events
	Signaling events mediated by PTP1B
	IL12-mediated signaling events
	S1P3 pathway
	SHP2 signaling
	CXCR4-mediated signaling events
	IL5-mediated signaling events
	IFN-gamma pathway
	ErbB2/ErbB3 signaling events
	IL3-mediated signaling events
	IL6-mediated signaling events
	PDGFR-beta signaling pathway
	IL23-mediated signaling events
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	Notch-mediated HES/HEY networkil4_2pathway:IL4-mediated signaling events
	CD40/CD40L signaling
	Signaling events mediated by TCPTP
	IL2-mediated signaling events
	IL2 signaling events mediated by PI3K
	IL2 signaling events mediated by STAT5ret_pathway:Signaling events regulated by Ret tyrosine kinase
	Posttranslational regulation of adherens junction stability and dissassembly
Reactome	Interleukin-6 signaling
	MAPK3 (ERK1) activation
	MAPK1 (ERK2) activation
	GPVI-mediated activation cascade
	Prolactin receptor signaling
	RMTs methylate histone arginines
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF activation
	RAF/MAP kinase cascade
	Interferon gamma signaling
	Regulation of IFNG signaling
	Interleukin receptor SHC signaling
	Growth hormone receptor signaling
	Factors involved in megakaryocyte development and platelet productionR-HSA-2033514:FGFR3 mutant receptor activationR-HSA-170984:ARMS-mediated activation
	NGF-independant TRKA activation
	PI3K/AKT activationR-HSA-114604:GPVI-mediated activation cascade
	Interleukin-7 signaling
	Interleukin-2 signaling
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Type II interferon signaling (IFNG)
	Notch Signaling Pathway
	EPO Receptor Signaling
	EGF/EGFR Signaling Pathway
	IL-4 Signaling Pathway
	IL-6 signaling pathway
	Kit receptor signaling pathway
	IL-3 Signaling Pathway
	Mesodermal Commitment Pathway
	Interleukin-2 signaling
	Signaling by SCF-KIT
	Prolactin receptor signaling
	Growth hormone receptor signaling
	JAK/STAT
	BDNF signaling pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TSLP Signaling Pathway
	IL17 signaling pathway
	Leptin signaling pathway
	TSH signaling pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interferon gamma signaling
	Factors involved in megakaryocyte development and platelet production
	IL-5 Signaling PathwayWP51:Regulation of Actin Cytoskeleton
	Endochondral Ossification
	Bladder Cancer
	Neural Crest Differentiation
	Signaling by FGFRWP382:MAPK Signaling Pathway
	Integrated Pancreatic Cancer Pathway
	NGF signalling via TRKA from the plasma membraneWP49:IL-2 Signaling Pathway
	Interleukin-7 signaling
	IL-9 Signaling Pathway
	IL-7 Signaling Pathway
	Interleukin-3, 5 and GM-CSF signalingWP706:SIDS Susceptibility Pathways
	Dopaminergic Neurogenesis
References
Ref 531435	In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61.
Ref 531435	In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61.

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Drug Information