Drug Information

Drug General Information
Drug ID
D05GOP
Former ID
DIB019821
Drug Name
EPPTB
Synonyms
Ro 5212773; Ro5212773; Ro-5212773
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540858]
Formula
C20H21F3N2O2
InChI
InChI=1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26)
InChIKey
KLFVWQCQUXXLOU-UHFFFAOYSA-N
PubChem Compound ID
25175634
PubChem Substance ID
57281822, 85022444, 124964641, 125086307, 137368129, 144240222, 162221594, 178102107, 229646135, 245842702, 249626946, 249895988, 252158133, 252160996
Target and Pathway
Target(s) Trace amine-associated receptor-1 Target Info Antagonist [530500]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
References
Ref 540858(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5457).
Ref 530500The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20081-6.

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