TTD | Drug: D04TLI

Drug General Information
Drug ID	D04TLI
Former ID	DIB019364
Drug Name	compound 23
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528928]
Formula	C17H17N5O3S
InChI	InChI=1S/C17H17N5O3S/c1-11-5-6-13(23)10-15(11)21-16-7-8-19-17(22-16)20-12-3-2-4-14(9-12)26(18,24)25/h2-10,23H,1H3,(H2,18,24,25)(H2,19,20,21,22)
InChIKey	LKLIRPMEYRVLFV-UHFFFAOYSA-N
PubChem Compound ID	23657507
PubChem Substance ID	46529899, 56035367, 56464603, 103551394, 180398604, 249565826
Target and Pathway
Target(s)	TXK tyrosine kinase	Target Info	Inhibitor	[528928]
	Tyrosine-protein kinase SYK	Target Info	Inhibitor	[528928]
	Lyn tyrosine kinase	Target Info	Inhibitor	[528928]
	Lck tyrosine kinase	Target Info	Inhibitor	[528928]
KEGG Pathway	NF-kappa B signaling pathway
	PI3K-Akt signaling pathway
	Osteoclast differentiation
	Platelet activation
	Natural killer cell mediated cytotoxicity
	B cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Tuberculosis
	Epstein-Barr virus infection
	Viral carcinogenesishsa04062:Chemokine signaling pathway
	Long-term depression
	Epithelial cell signaling in Helicobacter pylori infection
	Viral carcinogenesishsa04064:NF-kappa B signaling pathway
	T cell receptor signaling pathway
	HTLV-I infection
	Primary immunodeficiency
NetPath Pathway	IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	B cell activationP00010:B cell activation
	Parkinson disease
	CCKR signaling map STP00049:Parkinson disease
	T cell activation
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	BCR signaling pathway
	GMCSF-mediated signaling events
	Atypical NF-kappaB pathway
	Osteopontin-mediated events
	FAS (CD95) signaling pathway
	Thromboxane A2 receptor signaling
	IL2-mediated signaling events
	Class I PI3K signaling events
	Alpha-synuclein signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
	LPA receptor mediated events
	Glypican 1 network
	Signaling events mediated by PTP1B
	Regulation of p38-alpha and p38-beta
	CXCR4-mediated signaling events
	IL5-mediated signaling events
	amb2 Integrin signaling
	EPHA forward signaling
	PDGFR-beta signaling pathway
	IL8- and CXCR2-mediated signaling events
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	IL8- and CXCR1-mediated signaling events
	Ephrin B reverse signaling
	Alpha-synuclein signalingnfkappabatypicalpathway:Atypical NF-kappaB pathway
	TCR signaling in na&#xef
	IL12-mediated signaling events
	TCR signaling in na&#xef
	SHP2 signaling
	IL2 signaling events mediated by PI3K
	IL2 signaling events mediated by STAT5
	Alpha-synuclein signaling
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Reactome	GPVI-mediated activation cascade
	FCGR activation
	Regulation of actin dynamics for phagocytic cup formation
	Role of phospholipids in phagocytosis
	DAP12 signaling
	Fc epsilon receptor (FCERI) signaling
	Role of LAT2/NTAL/LAB on calcium mobilization
	FCERI mediated MAPK activation
	FCERI mediated Ca+2 mobilization
	Integrin alphaIIb beta3 signaling
	Interleukin-2 signaling
	CLEC7A (Dectin-1) signaling
	Dectin-2 family
	Regulation of signaling by CBL
	Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-114604:GPVI-mediated activation cascade
	Regulation of KIT signaling
	Cell surface interactions at the vascular wall
	PECAM1 interactions
	EPH-Ephrin signaling
	FCERI mediated NF-kB activation
	CD28 co-stimulation
	CTLA4 inhibitory signaling
	EPHB-mediated forward signaling
	EPHA-mediated growth cone collapse
	EPH-ephrin mediated repulsion of cells
	CD209 (DC-SIGN) signaling
	Platelet Adhesion to exposed collagen
	Growth hormone receptor signaling
	PIP3 activates AKT signaling
	Phosphorylation of CD3 and TCR zeta chains
	Translocation of ZAP-70 to Immunological synapse
	Generation of second messenger molecules
	Constitutive Signaling by Aberrant PI3K in Cancer
	CD28 dependent PI3K/Akt signaling
	CD28 dependent Vav1 pathway
	PD-1 signaling
WikiPathways	IL-2 Signaling Pathway
	IL-3 Signaling Pathway
	Fc epsilon receptor (FCERI) signaling
	Signaling by the B Cell Receptor (BCR)
	Interleukin-2 signaling
	Fcgamma receptor (FCGR) dependent phagocytosis
	DAP12 interactions
	B Cell Receptor Signaling Pathway
	RANKL/RANK Signaling Pathway
	Integrin alphaIIb beta3 signaling
	GPVI-mediated activation cascade
	Regulation of toll-like receptor signaling pathway
	IL-5 Signaling PathwayWP304:Kit receptor signaling pathway
	Signaling by SCF-KIT
	Growth hormone receptor signaling
	TSLP Signaling Pathway
	Platelet Adhesion to exposed collagen
	Costimulation by the CD28 family
	Cell surface interactions at the vascular wall
	IL-5 Signaling PathwayWP61:Notch Signaling Pathway
	Interferon type I signaling pathways
	Inflammatory Response Pathway
	Host Interactions of HIV factors
	PIP3 activates AKT signaling
	T-Cell Receptor and Co-stimulatory Signaling
	TCR signaling
References
Ref 528928	Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. Epub 2007 Apr 13.N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Ref 528928	Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. Epub 2007 Apr 13.N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.

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Drug Information