TTD | Drug: D07GEL

Drug General Information
Drug ID	D07GEL
Former ID	DIB020958
Drug Name	SL422
Synonyms	analogue 55f [PMID: 11472217]
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526113]
Formula	C23H34N4O6
InChI	InChI=1S/C23H34N4O6/c1-14(2)11-18-17(22(30)27-32)5-4-10-33-16-8-6-15(7-9-16)12-19(26-21(18)29)23(31)25-13-20(28)24-3/h6-9,14,17-19,32H,4-5,10-13H2,1-3H3,(H,24,28)(H,25,31)(H,26,29)(H,27,30)/t17-,18+,19-/m0/s1
InChIKey	HFAGTNGCAZYYLZ-OTWHNJEPSA-N
PubChem Compound ID	10344307
PubChem Substance ID	15355805, 22708247, 33977359, 79182605, 103297770, 103999108, 140922027, 228016718, 243922754, 252166829
Target and Pathway
Target(s)	MMP16	Target Info	Inhibitor	[526113]
	Matrilysin	Target Info	Inhibitor	[526113]
	Collagenase 3	Target Info	Inhibitor	[526113]
	ADAM 17	Target Info	Inhibitor	[526113]
	MMP-9	Target Info	Inhibitor	[526113]
	Neutrophil collagenase	Target Info	Inhibitor	[526113]
	MMP15	Target Info	Inhibitor	[526113]
KEGG Pathway	Wnt signaling pathwayhsa04330:Notch signaling pathway
	Alzheimer's disease
	Epithelial cell signaling in Helicobacter pylori infectionhsa04668:TNF signaling pathway
	Leukocyte transendothelial migration
	Estrogen signaling pathway
	Hepatitis B
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Bladder cancer
NetPath Pathway	Wnt Signaling PathwayNetPath_13:IL1 Signaling PathwayNetPath_5:ID Signaling Pathway
	TWEAK Signaling Pathway
	Leptin Signaling Pathway
	TNFalpha Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Wnt signaling pathway
	CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
	Plasminogen activating cascadeP00003:Alzheimer disease-amyloid secretase pathway
	Notch signaling pathwayP00004:Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
Pathway Interaction Database	Posttranslational regulation of adherens junction stability and dissassembly
	p75(NTR)-mediated signaling
	Syndecan-1-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingerbb4_pathway:ErbB4 signaling events
	TNF receptor signaling pathway
	p75(NTR)-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Validated targets of C-MYC transcriptional activation
	CXCR4-mediated signaling events
	amb2 Integrin signaling
	Syndecan-4-mediated signaling events
	AP-1 transcription factor network
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Syndecan-1-mediated signaling events
	Regulation of nuclear beta catenin signaling and target gene transcription
	FGF signaling pathway
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
	Assembly of collagen fibrils and other multimeric structuresR-HSA-1251985:Nuclear signaling by ERBB4
	Regulated proteolysis of p75NTR
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 t(7
	M1580_K2555) Translocation Mutant
	Constitutive Signaling by NOTCH1 HD Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	TNF signaling
	Growth hormone receptor signalingR-HSA-1442490:Collagen degradation
	Assembly of collagen fibrils and other multimeric structures
	EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
WikiPathways	Wnt Signaling Pathway and Pluripotency
	Activation of Matrix Metalloproteinases
	AGE/RAGE pathway
	Matrix MetalloproteinasesWP474:Endochondral Ossification
	Oncostatin M Signaling Pathway
	Matrix MetalloproteinasesWP61:Notch Signaling Pathway
	Copper homeostasis
	Notch Signaling Pathway
	Growth hormone receptor signaling
	BDNF signaling pathway
	Alzheimers Disease
	Signalling by NGF
	Extrinsic Pathway for ApoptosisWP474:Endochondral Ossification
	IL1 and megakaryotyces in obesity
	Mammary gland development pathway - Involution (Stage 4 of 4)
	Degradation of collagen
	Spinal Cord Injury
	TWEAK Signaling Pathway
	Angiogenesis
	Osteopontin Signaling
	Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
	Matrix Metalloproteinases
References
Ref 526113	Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60.
Ref 526113	Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60.

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Drug Information