Drug Information

Drug General Information
Drug ID
D0X7IC
Former ID
DIB020530
Drug Name
NG-25
Synonyms
NG25
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532902]
Formula
C29H30F3N5O2
InChI
InChI=1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)
InChIKey
SMPGEBOIKULBCT-UHFFFAOYSA-N
PubChem Compound ID
53340664
PubChem Substance ID
125005604, 152258717, 160647553, 163782655, 185975419, 196679411, 249565754, 252480202
Target and Pathway
Target(s) Proto-oncogene tyrosine-protein kinase SRC Target Info Inhibitor [532902]
c-src tyrosine kinase Target Info Inhibitor [532902]
Lyn tyrosine kinase Target Info Inhibitor [532902]
Mitogen-activated protein kinase kinase kinase 7 Target Info Inhibitor [532902]
mitogen-activated protein kinase kinase kinase kinase 2 Target Info Inhibitor [532902]
KEGG Pathway ErbB signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Endocytosis
VEGF signaling pathway
Focal adhesion
Adherens junction
Tight junction
Gap junction
Platelet activation
GABAergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Tuberculosis
Hepatitis B
Viral carcinogenesis
Proteoglycans in cancerhsa04062:Chemokine signaling pathway
NF-kappa B signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term depression
Epstein-Barr virus infection
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
PANTHER Pathway Angiogenesis
Cadherin signaling pathway
Integrin signalling pathway
Parkinson disease
CCKR signaling map STP00010:B cell activation
CCKR signaling map STP00052:TGF-beta signaling pathway
Toll receptor signaling pathway
Wnt signaling pathway
p38 MAPK pathway
Pathway Interaction Database Endothelins
Signaling events mediated by PRL
LPA receptor mediated events
Atypical NF-kappaB pathway
Glypican 1 network
Plasma membrane estrogen receptor signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
S1P3 pathway
EPHB forward signaling
Nectin adhesion pathway
Regulation of p38-alpha and p38-beta
CDC42 signaling events
Signaling events regulated by Ret tyrosine kinase
Arf6 signaling events
Signaling events mediated by TCPTP
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
Netrin-mediated signaling events
Alpha9 beta1 integrin signaling events
CXCR4-mediated signaling events
EGF receptor (ErbB1) signaling pathway
Class I PI3K signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Regulation of Androgen receptor activity
E-cadherin signaling in the nascent adherens junction
amb2 Integrin signaling
Integrins in angiogenesis
ErbB1 downstream signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
ErbB2/ErbB3 signaling events
EPHA forward signaling
E-cadherin signaling in keratinocytes
PDGFR-beta signaling pathway
Nongenotropic Androgen signaling
Internalization of ErbB1
CXCR3-mediated signaling events
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-2-mediated signaling events
Class I PI3K signaling events mediated by Akt
Syndecan-3-mediated signaling events
Ephrin B reverse signaling
Trk receptor signaling mediated by PI3K and PLC-gamma
EPHA2 forward signaling
Alpha-synuclein signaling
FGF signaling pathway
Alpha4 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinasefcer1pathway:Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
GMCSF-mediated signaling events
IL5-mediated signaling events
IL8- and CXCR2-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
IL8- and CXCR1-mediated signaling events
Alpha-synuclein signalingbcr_5pathway:BCR signaling pathway
p38 MAPK signaling pathway
Noncanonical Wnt signaling pathway
Presenilin action in Notch and Wnt signaling
IL1-mediated signaling events
TNF receptor signaling pathway
BMP receptor signaling
JNK signaling in the CD4+ TCR pathway
C-MYB transcription factor network
TGF-beta receptor signaling
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-1169091:Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
TRAF6 mediated induction of TAK1 complex
WikiPathways ErbB Signaling Pathway
Senescence and Autophagy in Cancer
Notch Signaling Pathway
EPO Receptor Signaling
EGF/EGFR Signaling Pathway
TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Pregnane X Receptor pathway
Aryl Hydrocarbon Receptor Pathway
IL-3 Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Polycystic Kidney Disease Pathway
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
Signaling Pathways in Glioblastoma
TSLP Signaling Pathway
Arylhydrocarbon receptor (AhR) signaling pathway
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
Integrin-mediated Cell Adhesion
Angiogenesis
Androgen receptor signaling pathwayWP304:Kit receptor signaling pathway
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Signaling by SCF-KIT
Growth hormone receptor signaling
B Cell Receptor Signaling Pathway
Platelet Adhesion to exposed collagen
GPVI-mediated activation cascade
Costimulation by the CD28 family
Cell surface interactions at the vascular wall
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
Insulin Signaling
p38 MAPK Signaling Pathway
Wnt Signaling Pathway and Pluripotency
MAPK Signaling Pathway
IL-6 signaling pathway
FAS pathway and Stress induction of HSP regulation
NLR Proteins
MyD88 cascade initiated on plasma membrane
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
MyD88 dependent cascade initiated on endosome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent cascade
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Structural Pathway of Interleukin 1 (IL-1)
EBV LMP1 signaling
TNF alpha Signaling Pathway
IL17 signaling pathway
TWEAK Signaling Pathway
IL-1 signaling pathway
TCR signaling
Interleukin-1 signaling
Regulation of toll-like receptor signaling pathway
References
Ref 532902Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.
Ref 532902Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.

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