TTD | Drug: D03RIO

Drug General Information
Drug ID	D03RIO
Former ID	DCL000383
Drug Name	GSK598809
Indication	Drug abuse [ICD9: 303-304; ICD10:F10-F19]		Phase 2	[523147]
Company	GSK
Target and Pathway
Target(s)	D(3) dopamine receptor	Target Info	Antagonist	[550963]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Dopaminergic synapse
Reactome	Dopamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 523147	ClinicalTrials.gov (NCT01188967) Effectiveness of GSK598809, a Selective D3 Antagonist, Added to Cognitive Behavioral Therapy and Nicotine Replacement Therapy for Smoking Cessation and Prevention of Very Early Relapse to Smoking. U.S. National Institutes of Health.
Ref 550963	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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Drug Information