Drug Information

Drug General Information
Drug ID
D02UJD
Former ID
DIB001806
Drug Name
PD-143188
Synonyms
PD-147693; PD-149394; PD-155144; PD-163637; PD-163639
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 2 [546028]
Company
Parke-Davis & Co
Formula
C24H27N
Canonical SMILES
C1(=CCC[C@H](C1)CN1CC=C(CC1)c1ccccc1)c1ccccc1
CAS Number
CAS 150013-70-0
PubChem Compound ID
127698
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [534559]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 546028Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005971)
Ref 534559Anxiolytic effects of dopamine receptor ligands: I. Involvement of dopamine autoreceptors. Life Sci. 1998;62(7):649-63.

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