Drug Information

Drug General Information
Drug ID
D08HDD
Former ID
DIB009195
Drug Name
RP-58802B
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [544951]
Company
Rhone-Poulenc SA
Formula
C20H25N3O3
Canonical SMILES
n1cn(c2c1cccc2)CCC(NCC(c1cc(c(cc1)O)OC)O)C.Cl.Cl
CAS Number
CAS 88578-14-7
PubChem Compound ID
65665
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Modulator [526640]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 544951Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001694)
Ref 526640RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. Pulm Pharmacol. 1992 Sep;5(3):203-12.

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