Drug Information

Drug General Information
Drug ID
D0B7LK
Former ID
DIB001914
Drug Name
CY-1503
Synonyms
Cylexin
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 2/3 [521727]
Company
Epimmune Inc
CAS Number
CAS 168678-84-0
Target and Pathway
Target(s) P-selectin Target Info Modulator [533630]
E-selectin Target Info Modulator [533630]
KEGG Pathway Cell adhesion molecules (CAMs)
Malaria
Staphylococcus aureus infectionhsa04514:Cell adhesion molecules (CAMs)
TNF signaling pathway
African trypanosomiasis
NetPath Pathway IL5 Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
ID Signaling Pathway
Pathway Interaction Database IL4-mediated signaling events
amb2 Integrin signalingtxa2pathway:Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
ATF-2 transcription factor network
Reactome Platelet degranulation
Cell surface interactions at the vascular wallR-HSA-202733:Cell surface interactions at the vascular wall
WikiPathways Human Complement System
Spinal Cord Injury
Cell surface interactions at the vascular wallWP2806:Human Complement System
TNF alpha Signaling Pathway
Cell surface interactions at the vascular wall
References
Ref 521727ClinicalTrials.gov (NCT00226369) Cylexin for Reduction of Reperfusion Injury in Infant Heart Surgery. U.S. National Institutes of Health.
Ref 533630Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation. 1995 Aug 1;92(3):492-9.

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