Drug Information

Drug General Information
Drug ID
D09ZKB
Former ID
DIB014078
Drug Name
Ad35-GRIN/ENV
Synonyms
Ad35 vector-delivered gag/rt/int/nef + Ad35 vector-delivered env combination vaccine (HIV infection), International AIDS Vaccine Initiative
Drug Type
Vaccine
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 1 [523741]
Company
International AIDS Vaccine Initiative
Target and Pathway
Target(s) HIV reverse transcriptase Target Info [531994]
HIV env Target Info [531994]
Negative factor Target Info [531994]
HIV REV protein Target Info [531994]
HIV GAG protein Target Info [531994]
Reactome Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
2-LTR circle formation
Binding and entry of HIV virion
Assembly Of The HIV Virion
Integration of viral DNA into host genomic DNA
Autointegration results in viral DNA circles
APOBEC3G mediated resistance to HIV-1 infection
Vpr-mediated nuclear import of PICsR-HSA-162585:Uncoating of the HIV Virion
Membrane binding and targetting of GAG proteins
Vpr-mediated nuclear import of PICs
WikiPathways Host Interactions of HIV factors
HIV Life CycleWP2684:Host Interactions of HIV factors
HIV Life Cycle
References
Ref 523741ClinicalTrials.gov (NCT01496989) Safety and Immunogenicity Study of HIV-MAG Vaccine +/- IL-12 and Ad35-GRIN/ENV in HIV-uninfected Volunteers. U.S. National Institutes of Health.
Ref 531994A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936.

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