Target Information

Target General Infomation
Target ID
T59729
Former ID
TTDR00862
Target Name
Aspartate-semialdehydedehydrogenase
Gene Name
asd2
Synonyms
ASA dehydrogenase; ASADH; L-Aspartate-beta-semialdehyde dehydrogenase; asd2
Target Type
Research
Function
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate.
BioChemical Class
Oxidoreductases acting on aldehyde or oxo group of donors
Target Validation
T59729
UniProt ID
P23247
EC Number
EC 1.2.1.11
Sequence
MSQQFNVAIFGATGAVGETMLEVLQEREFPVDELFLLASERSEGKTYRFNGKTVRVQNVE
EFDWSQVHIALFSAGGELSAKWAPIAAEAGVVVIDNTSHFRYDYDIPLVVPEVNPEAIAE
FRNRNIIANPNCSTIQMLVALKPIYDAVGIERINVTTYQSVSGAGKAGIDELAGQTAKLL
NGYPAETNTFSQQIAFNCIPQIDQFMDNGYTKEEMKMVWETQKIFNDPSIMVNPTCVRVP
VFYGHAEAVHVETRAPIDAEQVMDMLEQTDGIELFRGADFPTQVRDAGGKDHVLVGRVRN
DISHHSGINLWVVADNVRKGAATNAVQIAELLVRDYF
Inhibitor 2'-Monophosphoadenosine 5'-Diphosphoribose Drug Info [551393]
Aspartate Semialdehyde Drug Info [551393]
Cacodylate Ion Drug Info [551393]
S-sulpho-L-cysteine Drug Info [527572]
References
Ref 527572J Nat Prod. 2005 May;68(5):804-6.Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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