Drug Information

Drug General Information
Drug ID
D05CFH
Former ID
DCL000684
Drug Name
AGN-199981
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Phase 2 [536374]
Therapeutic Class
Analgesics
Company
Allergan
Target and Pathway
Target(s) Alpha-2B adrenergic receptor Target Info Agonist [536374]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signaling
References
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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