TTD | Drug: D08OLP

Drug General Information
Drug ID	D08OLP
Former ID	DNC003815
Drug Name	2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526118]
Formula	C15H14N3O+
Canonical SMILES	C1=CC=C(C(=C1)C2=CC3=C(N2)C=CC(=C3)C(=N)N)O
InChI	1S/C15H13N3O/c16-15(17)9-5-6-12-10(7-9)8-13(18-12)11-3-1-2-4-14(11)19/h1-8,18-19H,(H3,16,17)
InChIKey	JPGNPKIYCTXJPG-UHFFFAOYSA-N
PubChem Compound ID	1507
Target and Pathway
Target(s)	Trypsin	Target Info	Inhibitor	[526118]
	Coagulation factor IIa	Target Info	Inhibitor	[526118]
	Plasminogen	Target Info	Inhibitor	[526118]
	Urokinase-type plasminogen activator	Target Info	Inhibitor	[526118]
	Tissue-type plasminogen activator	Target Info	Inhibitor	[526118]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Pancreatic secretion
	Protein digestion and absorption
	Influenza Ahsa04080:Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
	Influenza Ahsa04064:NF-kappa B signaling pathway
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancerhsa04610:Complement and coagulation cascades
NetPath Pathway	TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
NetPath Pathway	EGFR1 Signaling PathwayNetPath_17:IL5 Signaling Pathway
PANTHER Pathway	Blood coagulationP00011:Blood coagulation
	Plasminogen activating cascadeP00011:Blood coagulation
	Plasminogen activating cascade
	CCKR signaling map STP00011:Blood coagulation
Pathway Interaction Database	Thrombin/protease-activated receptor (PAR) pathway
	Angiopoietin receptor Tie2-mediated signaling
	FOXA2 and FOXA3 transcription factor networks
	PAR4-mediated thrombin signaling events
	Syndecan-4-mediated signaling events
	PAR1-mediated thrombin signaling eventsangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
	p75(NTR)-mediated signaling
	amb2 Integrin signaling
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingintegrin1_pathway:Beta1 integrin cell surface interactions
	E2F transcription factor network
	Beta3 integrin cell surface interactions
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	ATF-2 transcription factor network
	AP-1 transcription factor network
	Beta2 integrin cell surface interactions
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	FGF signaling pathwayamb2_neutrophils_pathway:amb2 Integrin signaling
PathWhiz Pathway	Vitamin K Metabolism
PathWhiz Pathway	CoagulationPW000562:CoagulationPW000562:Coagulation
Reactome	Activation of Matrix Metalloproteinases
	Cobalamin (Cbl, vitamin B12) transport and metabolismR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Cell surface interactions at the vascular wall
	Peptide ligand-binding receptors
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	G alpha (q) signalling events
	Thrombin signalling through proteinase activated receptors (PARs)R-HSA-114608:Platelet degranulation
	Degradation of the extracellular matrix
	Dissolution of Fibrin ClotR-HSA-75205:Dissolution of Fibrin ClotR-HSA-75205:Dissolution of Fibrin Clot
WikiPathways	Activation of Matrix MetalloproteinasesWP558:Complement and Coagulation Cascades
	Regulation of Actin Cytoskeleton
	IL1 and megakaryotyces in obesity
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Gastrin-CREB signalling pathway via PKC and MAPK
	Thrombin signalling through proteinase activated receptors (PARs)
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signaling
	Formation of Fibrin Clot (Clotting Cascade)
	Cell surface interactions at the vascular wall
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
	Human Complement System
	Activation of Matrix Metalloproteinases
	Dissolution of Fibrin Clot
	Selenium Micronutrient NetworkWP710:DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Complement and Coagulation Cascades
	Endochondral Ossification
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Osteopontin SignalingWP615:Senescence and Autophagy in Cancer
	Selenium Micronutrient Network
References
Ref 526118	J Med Chem. 2001 Aug 16;44(17):2753-71.Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.
Ref 526118	J Med Chem. 2001 Aug 16;44(17):2753-71.Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.

Drug Information