Drug Information

Drug General Information
Drug ID
D09UXP
Former ID
DIB011493
Drug Name
AZD-1744
Synonyms
Dual CCR3/H-1 receptor antagonist (chronic obstructive pulmonary disease (COPD)), AstraZeneca
Indication Asthma [ICD10:J45] Discontinued in Phase 1 [548471]
Company
AstraZeneca plc
Target and Pathway
Target(s) C-C chemokine receptor type 3 Target Info Modulator [1572591]
Histamine H1 receptor Target Info Modulator [1572591]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesishsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL3 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
IL1 and megakaryotyces in obesity
IL-3 Signaling Pathway
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 548471Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025772)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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