Drug Information

Drug General Information
Drug ID
D0E8SE
Former ID
DIB013025
Drug Name
443C81
Synonyms
BW 443C; BW-443C81
Indication Asthma [ICD10:J45] Terminated [544585]
Company
Burroughs Wellcome Inc
Canonical SMILES
N1(C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(<br />cc2)O)N)CCCNC(=N)N)Cc2ccc([N+](=O)[O-])cc2)[C@H](C(=O)N<br />)CCC1
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Modulator [526731]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544585Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000227)
Ref 526731Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol (1985). 1992 Mar;72(3):1096-100.

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