TTD | Drug: D0JR3W

Drug General Information
Drug ID	D0JR3W
Former ID	DIB019377
Drug Name	compound 24
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[532248]
Formula	C29H27F3N6O
InChI	InChI=1S/C29H27F3N6O/c1-20-3-4-22(15-21(20)6-8-25-17-33-18-27-34-9-10-38(25)27)28(39)35-24-7-5-23(26(16-24)29(30,31)32)19-37-13-11-36(2)12-14-37/h3-5,7,9-10,15-18H,11-14,19H2,1-2H3,(H,35,39)
InChIKey	VSJSIOZQNZPUAV-UHFFFAOYSA-N
PubChem Compound ID	71605047
PubChem Substance ID	163689488, 164142876, 164156624, 249565827
Target and Pathway
Target(s)	ABL proto-oncogene 2, non-receptor tyrosine kinase	Target Info	Inhibitor	[532248]
Target(s)	mRNA of Abl	Target Info	Inhibitor	[532248]
KEGG Pathway	ErbB signaling pathway
	Ras signaling pathway
	Cell cycle
	Axon guidance
	Neurotrophin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Pathways in cancer
	MicroRNAs in cancer
	Chronic myeloid leukemia
	Viral myocarditis
PANTHER Pathway	Axon guidance mediated by Slit/Robo
Pathway Interaction Database	p73 transcription factor network
	ATM pathway
	Regulation of Telomerase
	Posttranslational regulation of adherens junction stability and dissassembly
	Lissencephaly gene (LIS1) in neuronal migration and development
	PDGFR-beta signaling pathway
	Neurotrophic factor-mediated Trk receptor signaling
	Validated transcriptional targets of TAp63 isoforms
	p53 pathway
	Regulation of retinoblastoma protein
Reactome	Regulation of actin dynamics for phagocytic cup formation
	CDO in myogenesis
	RHO GTPases Activate WASPs and WAVEs
	HDR through Single Strand Annealing (SSA)
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	Factors involved in megakaryocyte development and platelet production
WikiPathways	DNA Damage Response (only ATM dependent)
	DNA Damage Response
	ErbB Signaling Pathway
	EGF/EGFR Signaling Pathway
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Fcgamma receptor (FCGR) dependent phagocytosis
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Pathogenic Escherichia coli infection
	Regulation of Microtubule Cytoskeleton
	Integrated Breast Cancer Pathway
	Signaling by Robo receptor
	Myogenesis
	Factors involved in megakaryocyte development and platelet production
	TP53 Network
	miRNAs involved in DNA damage response
	miRNA Regulation of DNA Damage Response
References
Ref 532248	Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform. J Med Chem. 2013 Apr 11;56(7):3033-47.
Ref 532248	Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform. J Med Chem. 2013 Apr 11;56(7):3033-47.

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Drug Information