Drug Information

Drug General Information
Drug ID
D0K0IW
Former ID
DCL000093
Drug Name
CRA-028129
Indication Psoriatic disorder [ICD9: 696; ICD10:L40] Terminated [548110]
Company
Celera Genomics
Formula
C24H28N2O5
Target and Pathway
Target(s) Cathepsin S Target Info Inhibitor [551432]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosis
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLR
References
Ref 548110Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022029)
Ref 551432Phase I clinical trial for cathepsin S inhibitor for psoriasis begins. Celera Genomics. 2005.

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