Drug Information

Drug General Information
Drug ID
D0K1DC
Former ID
DIB013719
Drug Name
Romergoline
Synonyms
FCE-23884
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 2 [544873]
Company
Pharmacia & Upjohn AB
Formula
C20H22N4O2
Canonical SMILES
C12=C[C@H](CN([C@@H]1Cc1c3c2cccc3[nH]c1)C)CN1CC(=O)NC(=<br />O)C1
CAS Number
CAS 107052-56-2
PubChem Compound ID
65898
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [551899]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 544873Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001388)
Ref 551899CA patent application no. 648479, Implants for the treatment of dopamine associated states.

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