Drug Information

Drug General Information
Drug ID
D0L8IO
Former ID
DNCL001959
Drug Name
AVN 322
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 1 [549023]
Company
Avineuro Pharmaceuticals
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Modulator [544323]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 549023Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031585)
Ref 5443235-HT6 receptors and Alzheimer's disease. Alzheimers Res Ther. 2013; 5(2): 15.

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