Drug Information

Drug General Information
Drug ID
D0L9WN
Former ID
DNC012349
Drug Name
4-(4-Methyl-indan-1-yl)-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534467]
Formula
C13H14N2
Canonical SMILES
CC1=CC=CC2=C1CCC2C3=CN=CN3
InChI
1S/C13H14N2/c1-9-3-2-4-11-10(9)5-6-12(11)13-7-14-8-15-13/h2-4,7-8,12H,5-6H2,1H3,(H,14,15)
InChIKey
XXQLSAWUSXSJTK-UHFFFAOYSA-N
PubChem Compound ID
9990325
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [534467]
Alpha-2B adrenergic receptor Target Info Inhibitor [534467]
Alpha-2A adrenergic receptor Target Info Inhibitor [534467]
Alpha-1B adrenergic receptor Target Info Inhibitor [534467]
Alpha-1A adrenergic receptor Target Info Inhibitor [534467]
Alpha-2C adrenergic receptor Target Info Inhibitor [534467]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
Vitamin D Receptor Pathway
AMPK SignalingWP58:Monoamine GPCRs
Endothelin Pathways
References
Ref 534467J Med Chem. 1997 Sep 12;40(19):3014-24.Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket".
Ref 534467J Med Chem. 1997 Sep 12;40(19):3014-24.Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket".

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