Drug Information

Drug General Information
Drug ID
D0P3HP
Former ID
DNC012674
Drug Name
1,2,3,4,4a,5,10,10a-Octahydro-benzo[g]quinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534719]
Formula
C13H17N
Canonical SMILES
C1CC2CC3=CC=CC=C3CC2NC1
InChI
1S/C13H17N/c1-2-5-11-9-13-12(6-3-7-14-13)8-10(11)4-1/h1-2,4-5,12-14H,3,6-9H2
InChIKey
PXDWMPVOPNRION-UHFFFAOYSA-N
PubChem Compound ID
20186598
Target and Pathway
Target(s) Alpha-2B adrenergic receptor Target Info Inhibitor [534719]
Alpha-2A adrenergic receptor Target Info Inhibitor [534719]
Alpha-2C adrenergic receptor Target Info Inhibitor [534719]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signaling
References
Ref 534719J Med Chem. 1998 Oct 8;41(21):4165-70.N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.
Ref 534719J Med Chem. 1998 Oct 8;41(21):4165-70.N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.

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