Drug Information

Drug General Information
Drug ID
D0TH1Z
Former ID
DIB009415
Drug Name
Naxagolide
Synonyms
Dopazinol; Nazagolide; PHNO; Naxagolide hydrochloride; L-647339; MK-458; (+)-PHNO
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Discontinued in Phase 2 [545272]
Company
Merck & Co Inc
Formula
C15H21NO2
Canonical SMILES
[C@@H]12c3c(CC[C@H]1N(CCO2)CCC)ccc(c3)O
PubChem Compound ID
57533
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [533809]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 545272Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002657)
Ref 533809Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area. Br J Pharmacol. 1994 Jul;112(3):873-80.

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