Drug Information

Drug General Information
Drug ID
D0Z0KD
Former ID
DNC004249
Drug Name
PD-0183812
Drug Type
Small molecular drug
Indication Retinoblastoma [ICD10:C69.2] Terminated [547217]
Formula
C28H35N5O2
Canonical SMILES
C1CC2CC1CC2N3C(=O)C=CC4=CN=C(N=C43)NC5=CC=C(C=C5)N6CCC(<br />CC6)CCCO
InChI
1S/C28H35N5O2/c34-15-1-2-19-11-13-32(14-12-19)24-8-6-23(7-9-24)30-28-29-18-22-5-10-26(35)33(27(22)31-28)25-17-20-3-4-21(25)16-20/h5-10,18-21,25,34H,1-4,11-17H2,(H,29,30,31)
InChIKey
PETCVZZPKYJZAU-UHFFFAOYSA-N
PubChem Compound ID
5330258
Target and Pathway
Target(s) Cell division protein kinase 2 Target Info Inhibitor [525924]
Cyclin-A2 Target Info Inhibitor [525924]
Basic fibroblast growth factor receptor 1 Target Info Inhibitor [525924]
G1/S-specific cyclin E1 Target Info Inhibitor [525924]
mRNA of FGFR4 Target Info Inhibitor [525924]
FGF-3 receptor Target Info Inhibitor [525924]
Fibroblast growth factor receptor 2 Target Info Inhibitor [525924]
KEGG Pathway FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis B
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancerhsa03030:DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
HTLV-I infectionhsa04010:MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Proteoglycans in cancer
Melanoma
Central carbon metabolism in cancerhsa04110:Cell cycle
MicroRNAs in cancer
Small cell lung cancerhsa04010:MAPK signaling pathway
Endocytosis
Regulation of actin cytoskeletonhsa04010:MAPK signaling pathway
Bladder cancer
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
Central carbon metabolism in cancer
NetPath Pathway TCR Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway p53 pathway
p53 pathway feedback loops 2P00005:Angiogenesis
FGF signaling pathwayP00013:Cell cycle
Parkinson disease
p53 pathway feedback loops 2P00021:FGF signaling pathwayP00021:FGF signaling pathwayP00021:FGF signaling pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by PRL
p73 transcription factor network
E2F transcription factor network
ATR signaling pathway
mTOR signaling pathway
IL2-mediated signaling events
FoxO family signaling
FOXM1 transcription factor network
BARD1 signaling events
p53 pathway
Regulation of retinoblastoma proteinglypican_1pathway:Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathwayprlsignalingeventspathway:Signaling events mediated by PRL
PLK3 signaling events
Regulation of retinoblastoma proteinfgf_pathway:FGF signaling pathwayfgf_pathway:FGF signaling pathway
PathWhiz Pathway Nucleotide Excision Repair
Reactome G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
G2 Phase
Orc1 removal from chromatin
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet productionR-HSA-113510:E2F mediated regulation of DNA replication
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Homologous Recombination (HRR)
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
G1/S-Specific Transcription
Cyclin A:Cdk2-associated events at S phase entryR-HSA-113510:E2F mediated regulation of DNA replication
p53-Dependent G1 DNA Damage ResponseR-HSA-109704:PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascadeR-HSA-2033514:FGFR3 mutant receptor activationR-HSA-2033519:Activated point mutants of FGFR2
WikiPathways DNA Damage Response
ID signaling pathway
DNA Replication
G1 to S cell cycle control
M/G1 Transition
S Phase
Meiotic Recombination
Aryl Hydrocarbon Receptor
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Synthesis of DNA
Regulation of DNA replication
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Factors involved in megakaryocyte development and platelet production
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP615:Senescence and Autophagy in Cancer
Mismatch repair
EGF/EGFR Signaling Pathway
Nifedipine Activity
Primary Focal Segmental Glomerulosclerosis FSGS
Nucleotide Excision Repair
Telomere Maintenance
Base Excision RepairWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
MAPK Signaling Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Neural Crest Differentiation
Signaling by FGFRWP707:DNA Damage Response
Parkinsons Disease Pathway
Parkin-Ubiquitin Proteasomal System pathway
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
Androgen receptor signaling pathwayWP51:Regulation of Actin Cytoskeleton
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Signaling by FGFRWP51:Regulation of Actin Cytoskeleton
Bladder Cancer
Ectoderm Differentiation
Hair Follicle Development: Organogenesis (Part 2 of 3)
Cardiac Hypertrophic Response
Signaling by FGFR
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
References
Ref 547217Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014130)
Ref 525924J Med Chem. 2000 Nov 30;43(24):4606-16.Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.

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