Resistance mutation info of target

Target General Information
Target ID T13852
Target Name Sphingosine 1-phosphate receptor 1 (S1PR1) Target Info
Gene Name S1PR1
Species Homo sapiens
Uniprot ID S1PR1_HUMAN
Sequence MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 539536(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2407).
Mutation Info Missense: G305C
Drugs
Drug Name Fingolimod Drug Info [1559255]
Targeted Disease Multiple sclerosis
Mutation Info Missense: I45T
Drugs
Drug Name Fingolimod Drug Info [1559255]
Targeted Disease Multiple sclerosis
Reference
Ref 1559255Individual variation of human S1P?coding sequence leads to heterogeneity in receptor function and drug interactions.J Lipid Res.2014 Dec;55(12):2665-75.

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