TTD | Drug: D0T4MJ

Drug General Information
Drug ID	D0T4MJ
Former ID	DIB021001
Drug Name	K00592a
Synonyms	K00592a
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527614]
Formula	C14H15F3N6O
InChI	InChI=1S/C14H15F3N6O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23)
InChIKey	FQNFLNSVHWCZML-UHFFFAOYSA-N
PubChem Compound ID	9549296
PubChem Substance ID	14720362, 16415215, 23984868, 44692625, 51550025, 103595701, 104103646, 127885148, 137087818, 178102669, 180372413, 227455471
Target and Pathway
Target(s)	Tyrosine-protein kinase SYK	Target Info	Inhibitor	[527614]
Target(s)	Zap70 tyrosine kinase	Target Info	Inhibitor	[527614]
KEGG Pathway	NF-kappa B signaling pathway
	PI3K-Akt signaling pathway
	Osteoclast differentiation
	Platelet activation
	Natural killer cell mediated cytotoxicity
	B cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Tuberculosis
	Epstein-Barr virus infection
	Viral carcinogenesishsa04014:Ras signaling pathway
	T cell receptor signaling pathway
	Primary immunodeficiency
PANTHER Pathway	B cell activationP00053:T cell activation
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	BCR signaling pathway
	GMCSF-mediated signaling events
	Atypical NF-kappaB pathway
	Osteopontin-mediated events
	FAS (CD95) signaling pathway
	Thromboxane A2 receptor signaling
	IL2-mediated signaling events
	Class I PI3K signaling events
	Alpha-synuclein signalingtcr_pathway:TCR signaling in na&#xef
	TCR signaling in na&#xef
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
Reactome	GPVI-mediated activation cascade
	FCGR activation
	Regulation of actin dynamics for phagocytic cup formation
	Role of phospholipids in phagocytosis
	DAP12 signaling
	Fc epsilon receptor (FCERI) signaling
	Role of LAT2/NTAL/LAB on calcium mobilization
	FCERI mediated MAPK activation
	FCERI mediated Ca+2 mobilization
	Integrin alphaIIb beta3 signaling
	Interleukin-2 signaling
	CLEC7A (Dectin-1) signaling
	Dectin-2 family
	Regulation of signaling by CBL
	Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-202430:Translocation of ZAP-70 to Immunological synapse
	Generation of second messenger molecules
WikiPathways	IL-2 Signaling Pathway
	IL-3 Signaling Pathway
	Fc epsilon receptor (FCERI) signaling
	Signaling by the B Cell Receptor (BCR)
	Interleukin-2 signaling
	Fcgamma receptor (FCGR) dependent phagocytosis
	DAP12 interactions
	B Cell Receptor Signaling Pathway
	RANKL/RANK Signaling Pathway
	Integrin alphaIIb beta3 signaling
	GPVI-mediated activation cascade
	Regulation of toll-like receptor signaling pathway
	IL-5 Signaling PathwayWP69:TCR Signaling Pathway
	Interferon type I signaling pathways
	Inflammatory Response Pathway
	JAK/STAT
	T-Cell Receptor and Co-stimulatory Signaling
	TCR signaling
References
Ref 527614	Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.
Ref 527614	Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.

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Drug Information