Drug Information

Drug General Information
Drug ID
D00JMZ
Former ID
DNC011785
Drug Name
CGS-27830
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545827]
Formula
C32H30N4O11
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC(=O)C2=C(NC(=C(C2C3=CC(=CC=C3)<br />[N+](=O)[O-])C(=O)OC)C)C)C4=CC(=CC=C4)[N+](=O)[O-])C(=O<br />)OC
InChI
1S/C32H30N4O11/c1-15-23(29(37)45-5)27(19-9-7-11-21(13-19)35(41)42)25(17(3)33-15)31(39)47-32(40)26-18(4)34-16(2)24(30(38)46-6)28(26)20-10-8-12-22(14-20)36(43)44/h7-14,27-28,33-34H,1-6H3/t27-,28+
InChIKey
PZNZOWSLQRURNA-HNRBIFIRSA-N
PubChem Compound ID
190809
Target and Pathway
Target(s) Voltage-dependent L-type calcium channel alpha-1D subunit Target Info Inhibitor [551247]
Voltage-dependent L-type calcium channel subunit alpha-1C Target Info Inhibitor [551247]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Insulin secretion
GnRH signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Carbohydrate digestion and absorption
Alzheimer's disease
Amphetamine addiction
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04010:MAPK signaling pathway
Long-term potentiation
Dilated cardiomyopathy
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
5HT2 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Oxytocin receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenaline,noradrenaline inhibits insulin secretion
NCAM1 interactions
Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
Regulation of insulin secretion
WikiPathways Calcium Regulation in the Cardiac Cell
Arrhythmogenic Right Ventricular Cardiomyopathy
Alzheimers Disease
NCAM signaling for neurite out-growth
Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell
Integration of energy metabolism
Nicotine Activity on Chromaffin Cells
References
Ref 545827Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004940)
Ref 551247CGS 27830, a potent nonpeptide endothelin receptor antagonist, Bioorg. Med. Chem. Lett. 3(10):2099-2104 (1993).

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