Drug Information

Drug General Information
Drug ID
D0Q9ON
Former ID
DNAP001481
Drug Name
Denopamine
Synonyms
Kalgut (TN)
Drug Type
Small molecular drug
Indication Cardiotonic [ICD10:I50] Approved [540779], [551871]
Formula
C18H23NO4
InChI
InChI=1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
InChIKey
VHSBBVZJABQOSG-INIZCTEOSA-N
CAS Number
CAS 71771-90-9
PubChem Compound ID
5311064
PubChem Substance ID
7979038, 11056246, 11111097, 12012784, 15988323, 17396784, 24262988, 24278687, 39340792, 50652372, 57359342, 103604705, 104105652, 114155184, 129476746, 135650167, 144204824, 144225998, 162178834, 162247274, 164814601, 179151013, 198936797, 226572136, 241130735, 252359264
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [536361]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 540779(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 534).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.