Drug Information

Drug General Information
Drug ID
D07JRA
Former ID
DNC006427
Drug Name
3-isopropyl-4-phenylnaphthalene-1,2-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527986]
Formula
C19H16O2
Canonical SMILES
CC(C)C1=C(C2=CC=CC=C2C(=O)C1=O)C3=CC=CC=C3
InChI
1S/C19H16O2/c1-12(2)16-17(13-8-4-3-5-9-13)14-10-6-7-11-15(14)18(20)19(16)21/h3-12H,1-2H3
InChIKey
ZMFOKOSZYNMITK-UHFFFAOYSA-N
PubChem Compound ID
44409685
Target and Pathway
Target(s) M-phase inducer phosphatase 1 Target Info Inhibitor [527986]
M-phase inducer phosphatase 2 Target Info Inhibitor [527986]
KEGG Pathway Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancerhsa04010:MAPK signaling pathway
MicroRNAs in cancer
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling Pathway
Pathway Interaction Database E2F transcription factor network
ATR signaling pathway
Validated targets of C-MYC transcriptional activation
ATM pathwayplk1_pathway:PLK1 signaling events
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Aurora A signaling
Reactome E2F mediated regulation of DNA replication
G0 and Early G1
Polo-like kinase mediated events
Cyclin B2 mediated events
Activation of ATR in response to replication stress
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A/B1 associated events during G2/M transition
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entryR-HSA-157881:Cyclin B2 mediated events
Cyclin A:Cdk2-associated events at S phase entry
WikiPathways DNA Damage Response
G1 to S cell cycle control
S Phase
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G1-G1/S phases
Cell Cycle
Cell Cycle Checkpoints
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage ResponseWP615:Senescence and Autophagy in Cancer
MAPK Signaling Pathway
Mitotic G2-G2/M phases
References
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.