Drug Information

Drug General Information
Drug ID
D0R2NE
Former ID
DCL000795
Drug Name
Entacapone+levodopa+carbidopa
Indication Parkinson's disease; Restless legs syndrome [ICD9: 332, 333.94; ICD10:F02.3, G20, G25.8] Phase 3 [544058]
Company
Orion; Novartis
CAS Number
CAS 130929-57-6 + 59-92-7
SuperDrug ATC ID
N04BX02
SuperDrug CAS ID
cas=116314671
Target and Pathway
Target(s) Catechol-O-methyl-transferase Target Info Inhibitor [536121]
D(2) dopamine receptor Target Info Agonist [536121]
BioCyc Pathway L-dopa degradation
Dopamine degradation
Noradrenaline and adrenaline degradation
KEGG Pathway Steroid hormone biosynthesis
Tyrosine metabolism
Metabolic pathways
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Tyrosine Metabolism
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Methylation Pathways
Metapathway biotransformation
Estrogen metabolism
Biogenic Amine Synthesis
Dopamine metabolism
Phase II conjugation
Neurotransmitter Clearance In The Synaptic CleftWP666:Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 544058Optimizing levodopa therapy for Parkinson's disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective. Neuropsychiatr Dis Treat. 2008 February; 4(1): 39-47.
Ref 536121Emerging drugs for restless legs syndrome. Expert Opin Emerg Drugs. 2005 Aug;10(3):537-52.

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