Drug Information

Drug General Information
Drug ID
D0P5PW
Former ID
DNC004570
Drug Name
4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533805]
Formula
C15H14N2
Canonical SMILES
CC(C1=CC=CC2=CC=CC=C21)C3=CN=CN3
InChI
1S/C15H14N2/c1-11(15-9-16-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13/h2-11H,1H3,(H,16,17)
InChIKey
DZSQSLQSMKNVBV-UHFFFAOYSA-N
PubChem Compound ID
132111
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [533805]
Alpha-2B adrenergic receptor Target Info Inhibitor [533805]
Alpha-2C adrenergic receptor Target Info Inhibitor [533805]
Alpha-1D adrenergic receptor Target Info Inhibitor [533805]
Alpha-1B adrenergic receptor Target Info Inhibitor [533805]
Alpha-2A adrenergic receptor Target Info Inhibitor [533805]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Salivary secretionhsa04020:Calcium signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCRs, OtherWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
References
Ref 533805J Med Chem. 1994 Jul 22;37(15):2328-33.A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.
Ref 533805J Med Chem. 1994 Jul 22;37(15):2328-33.A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.

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