Drug Information

Drug General Information
Drug ID
D06WUE
Former ID
DNC010972
Drug Name
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551239]
Formula
C11H9Cl2NO2S2
Canonical SMILES
CC1=CC=C(C=C1)NS(=O)(=O)C2=C(SC(=C2)Cl)Cl
InChI
1S/C11H9Cl2NO2S2/c1-7-2-4-8(5-3-7)14-18(15,16)9-6-10(12)17-11(9)13/h2-6,14H,1H3
InChIKey
OQWXAWNHXDPWGS-UHFFFAOYSA-N
PubChem Compound ID
49798484
Target and Pathway
Target(s) Cyclin-A2 Target Info Inhibitor [551239]
Cell division protein kinase 7 Target Info Inhibitor [551239]
Cyclin-dependent protein kinase Pfmrk Target Info Inhibitor [551239]
KEGG Pathway DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
Cell cycle
Hepatitis B
HTLV-I infectionhsa03022:Basal transcription factors
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Retinoic acid receptors-mediated signaling
PathWhiz Pathway Nucleotide Excision Repair
Reactome E2F mediated regulation of DNA replication
G0 and Early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
G2 Phase
Orc1 removal from chromatin
G1/S-Specific Transcription
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entryR-HSA-427413:NoRC negatively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RNA Polymerase I Transcription Initiation
WikiPathways Senescence and Autophagy in Cancer
Mismatch repair
DNA Replication
G1 to S cell cycle control
EGF/EGFR Signaling Pathway
S Phase
Nifedipine Activity
Primary Focal Segmental Glomerulosclerosis FSGS
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Nucleotide Excision Repair
Telomere Maintenance
Synthesis of DNA
Mitotic G1-G1/S phases
Cell Cycle
Base Excision RepairWP45:G1 to S cell cycle control
Eukaryotic Transcription Initiation
Cardiac Hypertrophic Response
HIV Life Cycle
Integrated Breast Cancer Pathway
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
mRNA Capping
Mitotic G2-G2/M phases
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 551239Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).
Ref 551239Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).

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