TTD | Drug: D04ZWF

Drug General Information
Drug ID	D04ZWF
Former ID	DIB019122
Drug Name	CHIR-98014
Synonyms	CHIR98014; CHIR 98014
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525550]
Formula	C20H17Cl2N9O2
InChI	InChI=1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
InChIKey	MDZCSIDIPDZWKL-UHFFFAOYSA-N
PubChem Compound ID	53396311
PubChem Substance ID	125433223, 135697718, 136340338, 136349583, 136367714, 142855157, 144115821, 152133978, 160844853, 162011432, 162038226, 162205166, 163981443, 174007083, 174811344, 187071955, 210274829, 210280461, 223665986, 239648736, 241054897, 242588161, 245677292, 249565696, 252159882, 252451517
Target and Pathway
Target(s)	mRNA of human glycogen synthase kinase 3 alpha	Target Info	Inhibitor	[526553]
Target(s)	Glycogen synthase kinase-3 beta	Target Info	Inhibitor	[526553]
KEGG Pathway	Chemokine signaling pathway
	Dopaminergic synapse
	Non-alcoholic fatty liver disease (NAFLD)hsa04012:ErbB signaling pathway
	Cell cycle
	PI3K-Akt signaling pathway
	Wnt signaling pathway
	Hedgehog signaling pathway
	Axon guidance
	Hippo signaling pathway
	Focal adhesion
	Signaling pathways regulating pluripotency of stem cells
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Neurotrophin signaling pathway
	Insulin signaling pathway
	Melanogenesis
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Alzheimer's disease
	Hepatitis C
	Measles
	Influenza A
	HTLV-I infection
	Epstein-Barr virus infection
	Pathways in cancer
	Colorectal cancer
	Endometrial cancer
	Prostate cancer
	Basal cell carcinoma
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	PDGF signaling pathway
	Ras PathwayP00004:Alzheimer disease-presenilin pathway
	Angiogenesis
	Cadherin signaling pathway
	Hedgehog signaling pathway
	Interleukin signaling pathway
	PI3 kinase pathway
	Wnt signaling pathway
	Ras Pathway
	CCKR signaling map ST
Pathway Interaction Database	Degradation of beta catenin
	Canonical Wnt signaling pathway
	FOXM1 transcription factor network
	Class I PI3K signaling events mediated by Aktlysophospholipid_pathway:LPA receptor mediated events
	Reelin signaling pathway
	Presenilin action in Notch and Wnt signaling
	Integrin-linked kinase signaling
	CDC42 signaling events
	LKB1 signaling events
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Glucocorticoid receptor regulatory network
	C-MYC pathway
	Regulation of Androgen receptor activity
	BMP receptor signaling
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Validated transcriptional targets of deltaNp63 isoforms
	Aurora A signaling
	Insulin-mediated glucose transport
	Class I PI3K signaling events mediated by Akt
	p53 pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	AKT phosphorylates targets in the cytosol
	XBP1(S) activates chaperone genes
	Constitutive Signaling by AKT1 E17K in CancerR-HSA-195253:Degradation of beta-catenin by the destruction complex
	Regulation of HSF1-mediated heat shock response
	CRMPs in Sema3A signaling
	Disassembly of the destruction complex and recruitment of AXIN to the membrane
	S33 mutants of beta-catenin aren't phosphorylated
	S37 mutants of beta-catenin aren't phosphorylated
	S45 mutants of beta-catenin aren't phosphorylated
	T41 mutants of beta-catenin aren't phosphorylated
	Degradation of GLI2 by the proteasome
	Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways	Glycogen Metabolism
	Insulin Signaling
	Wnt Signaling Pathway Netpath
	Activation of Chaperone Genes by XBP1(S)
	T-Cell Receptor and Co-stimulatory Signaling
	Integrated Pancreatic Cancer Pathway
	B Cell Receptor Signaling Pathway
	Leptin signaling pathway
	Integrated Breast Cancer Pathway
	SREBP signalling
	IL-5 Signaling PathwayWP710:DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Notch Signaling Pathway
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	IL-6 signaling pathway
	Copper homeostasis
	Focal Adhesion
	Hair Follicle Development: Induction (Part 1 of 3)
	Cardiac Hypertrophic Response
	Degradation of beta-catenin by the destruction complex
	Cardiac Progenitor Differentiation
	BDNF signaling pathway
	Corticotropin-releasing hormone
	IL17 signaling pathway
	Neural Crest Differentiation
	Alzheimers Disease
	IL-7 Signaling Pathway
	Regulation of Microtubule Cytoskeleton
	TWEAK Signaling Pathway
	Semaphorin interactions
	Cell Cycle
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathway
	IL-5 Signaling Pathway
References
Ref 525550	Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes. 1999 Aug;48(8):1662-6.
Ref 526553	Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

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Drug Information