TTD | Drug: D0NP8A

Drug General Information
Drug ID	D0NP8A
Former ID	DNC003632
Drug Name	UK-356618
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541656]
Formula	C34H43N3O4
InChI	InChI=1S/C34H43N3O4/c1-23-21-25(19-20-29(23)27-16-10-7-11-17-27)13-12-18-28(22-30(38)37-41)32(39)36-31(34(3,4)5)33(40)35-24(2)26-14-8-6-9-15-26/h6-11,14-17,19-21,24,28,31,41H,12-13,18,22H2,1-5H3,(H,35,40)(H,36,39)(H,37,38)/t24-,28-,31-/m1/s1
InChIKey	JJHRUUKMPWUYIB-HVOSOHGQSA-N
PubChem Compound ID	10370504
PubChem Substance ID	15384061, 22727485, 34003512, 76084287, 103344207, 103994595, 134340837, 140323975, 142602888, 162249043, 164766040, 177748920, 178103142, 232160792, 241376854, 248386042, 249618099, 252157855, 252160740
Target and Pathway
Target(s)	MMP-9	Target Info	Inhibitor	[526680]
	Stromelysin-1	Target Info	Inhibitor	[526680]
	72 kDa type IV collagenase	Target Info	Inhibitor	[526680]
	Collagenase 3	Target Info	Inhibitor	[526680]
	Matrix metalloproteinase-14	Target Info	Inhibitor	[526680]
KEGG Pathway	TNF signaling pathway
	Leukocyte transendothelial migration
	Estrogen signaling pathway
	Hepatitis B
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Bladder cancerhsa04668:TNF signaling pathway
	Rheumatoid arthritishsa04670:Leukocyte transendothelial migration
	GnRH signaling pathway
NetPath Pathway	ID Signaling Pathway
	TWEAK Signaling Pathway
	Leptin Signaling Pathway
	TNFalpha Signaling PathwayNetPath_13:IL1 Signaling Pathway
	IL4 Signaling PathwayNetPath_22:Leptin Signaling Pathway
	TCR Signaling Pathway
	ID Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
	CCKR signaling map STP00050:Plasminogen activating cascade
	CCKR signaling map STP00004:Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
	Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database	LPA receptor mediated events
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Validated targets of C-MYC transcriptional activation
	CXCR4-mediated signaling events
	amb2 Integrin signaling
	Syndecan-4-mediated signaling events
	AP-1 transcription factor network
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Syndecan-1-mediated signaling events
	Regulation of nuclear beta catenin signaling and target gene transcription
	FGF signaling pathwayajdiss_2pathway:Posttranslational regulation of adherens junction stability and dissassembly
	p75(NTR)-mediated signaling
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
	Angiopoietin receptor Tie2-mediated signaling
	Direct p53 effectors
	ATF-2 transcription factor network
	FOXM1 transcription factor network
	Syndecan-2-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalinghif2pathway:HIF-2-alpha transcription factor network
	Signaling events mediated by focal adhesion kinase
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structures
	EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
	EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
WikiPathways	Endochondral Ossification
	IL1 and megakaryotyces in obesity
	Mammary gland development pathway - Involution (Stage 4 of 4)
	Activation of Matrix Metalloproteinases
	Degradation of collagen
	Spinal Cord Injury
	AGE/RAGE pathway
	TWEAK Signaling Pathway
	Angiogenesis
	Osteopontin Signaling
	Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
	Gastrin-CREB signalling pathway via PKC and MAPK
	Oncostatin M Signaling Pathway
	Matrix MetalloproteinasesWP474:Endochondral Ossification
	Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer
	Matrix Metalloproteinases
References
Ref 541656	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6528).
Ref 526680	J Med Chem. 2003 Jul 31;46(16):3514-25.A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.

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Drug Information