TTD | Drug: D08KDP

Drug General Information
Drug ID	D08KDP
Former ID	DNC000257
Drug Name	AS-8112
Indication	Emesis [ICD9: 787; ICD10:R11]		Terminated	[546591]
Company	Dainippon
CAS Number	CAS 13074-00-5
Target and Pathway
Target(s)	5-hydroxytryptamine receptor 3A	Target Info	Antagonist	[536188]
Target(s)	D(3) dopamine receptor	Target Info	Antagonist	[536188]
KEGG Pathway	Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
KEGG Pathway	Dopaminergic synapse
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	5HT3 type receptor mediated signaling pathway
Reactome	Ligand-gated ion channel transportR-HSA-390651:Dopamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Iron uptake and transportWP58:Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 546591	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009088)
Ref 536188	Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51.

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Drug Information