Drug Information

Drug General Information
Drug ID
D0EW9J
Former ID
DIB019260
Drug Name
compound 16
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528819]
Formula
C21H16N4O
InChI
InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26)
InChIKey
OWFLADWRSCINST-UHFFFAOYSA-N
PubChem Compound ID
10389239
PubChem Substance ID
24424088, 24424089, 26674159, 34108847, 46535316, 53812745, 53812746, 79074072, 85147945, 87692623, 99444829, 103517294, 103905260, 123050905, 137183924, 143313394, 160969401, 170482403, 172844963, 180387188, 203091265, 208012403, 231968660, 245808241, 249565857
Target and Pathway
Target(s) mitogen-activated protein kinase-activated protein kinase 3 Target Info Inhibitor [528819]
MAPKAPK5 Target Info Inhibitor [528819]
MAPKAP kinase 2 Target Info Inhibitor [528819]
KEGG Pathway MAPK signaling pathway
VEGF signaling pathway
Neurotrophin signaling pathway
Viral carcinogenesis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
Interleukin signaling pathway
PDGF signaling pathway
VEGF signaling pathway
Ras Pathway
p38 MAPK pathway
Pathway Interaction Database Signaling mediated by p38-alpha and p38-betail2_1pathway:IL2-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Signaling mediated by p38-alpha and p38-beta
Signaling events mediated by VEGFR1 and VEGFR2
Trk receptor signaling mediated by the MAPK pathway
Reactome Oxidative Stress Induced Senescence
MAPK6/MAPK4 signalingR-HSA-171007:p38MAPK events
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
WikiPathways p38 MAPK Signaling Pathway
MAPK Signaling PathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Serotonin HTR1 Group and FOS Pathway
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Arachidonic acid metabolism
Structural Pathway of Interleukin 1 (IL-1)
Regulation of Microtubule Cytoskeleton
IL-1 signaling pathway
NGF signalling via TRKA from the plasma membrane
MAPK targets/ Nuclear events mediated by MAP kinases
References
Ref 528819J Med Chem. 2007 May 31;50(11):2647-54. Epub 2007 May 5.Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Ref 528819J Med Chem. 2007 May 31;50(11):2647-54. Epub 2007 May 5.Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

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