Drug Information

Drug General Information
Drug ID
D0K2PS
Former ID
DIB000608
Drug Name
Carmoxirole
Synonyms
Carmoxirole hydrochloride; EMD-45609
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 1 [526775]
Company
Merck KGaA
Formula
C24H26N2O2
Canonical SMILES
c12cc(C(=O)O)ccc2[nH]cc1CCCCN1CC=C(CC1)c1ccccc1
PubChem Compound ID
57364
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [534755]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 526775Pharmacokinetics and first clinical experiences with an antihypertensive dopamine (DA2) agonist. Eur Heart J. 1992 Sep;13 Suppl D:121-8.
Ref 534755Neurohumoral response to carmoxirole, a selective dopamine (D2) receptor agonist, in patients with chronic moderate heart failure. Cardiovasc Drugs Ther. 1998 Sep;12(4):387-94.

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