Drug Information

Drug General Information
Drug ID
D0N8AB
Former ID
DIB012025
Drug Name
PF-4629991
Synonyms
PF-991; S1P1 receptor agonist (autoimmune disease), Pfizer
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Discontinued in Phase 1 [548892]
Company
Pfizer Inc
Canonical SMILES
n1c(onc1c1ccc(cc1)[C@H](N[C@@H]1C[C@@H](C1)C(=O)O)C)c1c<br />cc(cc1)CC(C)C
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [551919]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548892Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030004)
Ref 551919US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast.

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