Drug Information

Drug General Information
Drug ID
D0OZ4F
Former ID
DIB007760
Drug Name
Ordopidine
Synonyms
ACR-321; ACR-325
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Discontinued in Phase 1 [548392]
Company
A Carlsson Research AB
Formula
C14H20FNO2S
Canonical SMILES
c1c(c(c(cc1)C1CCN(CC1)CC)F)S(=O)(=O)C
CAS Number
CAS 871351-60-9
PubChem Compound ID
11701939
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [532776]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 548392Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025217)
Ref 532776The dopaminergic stabilizers pridopidine and ordopidine enhance cortico-striatal Arc gene expression. J Neural Transm. 2014 Nov;121(11):1337-47.

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