Drug Information

Drug General Information
Drug ID
D06PZC
Former ID
DIB011107
Drug Name
SAM-6
Drug Type
Antibody
Indication Melanoma [ICD9: 172; ICD10:C43] Phase 1 [524124]
Company
Pack of Parker; OncoMab GmbH
Target and Pathway
Target(s) 78 kDa glucose-regulated protein Target Info [529312]
KEGG Pathway Protein export
Protein processing in endoplasmic reticulum
Antigen processing and presentation
Thyroid hormone synthesis
Prion diseases
NetPath Pathway TSH Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Parkinson disease
PathWhiz Pathway Retinol Metabolism
Reactome Platelet degranulation
Regulation of HSF1-mediated heat shock response
WikiPathways MAPK Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Activation of Chaperone Genes by ATF6-alpha
Parkin-Ubiquitin Proteasomal System pathway
Unfolded Protein Response
Response to elevated platelet cytosolic Ca2+
References
Ref 524124ClinicalTrials.gov (NCT01727778) Safety and Preliminary Efficacy Study of the Antibody PAT-SM6 in Patients With Relapsed or Refractory Multiple Myeloma. U.S. National Institutes of Health.
Ref 529312A new tumor-specific variant of GRP78 as target for antibody-based therapy. Lab Invest. 2008 Apr;88(4):375-86.

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