Drug Information

Drug General Information
Drug ID
D01UHA
Former ID
DIB012100
Drug Name
MIS-416
Synonyms
Microparticle adjuvant (anthrax), Virionyx; Microparticle adjuvant (iv, autoimmune disease/cancer/anthrax), Innate Therapeutics
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 2 [549949]
Company
Innate Therapeutics Ltd
Target and Pathway
Target(s) Toll-like receptor 9 Target Info Modulator
Pattern recognition receptor NOD2 Target Info Modulator
KEGG Pathway Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Tuberculosis
Measles
Herpes simplex infectionhsa04621:NOD-like receptor signaling pathway
TNF signaling pathway
Shigellosis
Inflammatory bowel disease (IBD)
NetPath Pathway BCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Canonical NF-kappaB pathway
Reactome PI3K Cascade
Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosomeR-HSA-168638:NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of toll-like receptor signaling pathwayWP2792:MAP kinase activation in TLR cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
NOD pathway
References
Ref 549949Targeting Innate Receptors with MIS416 Reshapes Th Responses and Suppresses CNS Disease in a Mouse Model of Multiple Sclerosis. PLoS ONE 9(1): e87712. January 31, 2014.

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