General Information of HIF (ID: HIFC0009)
HIF Name	Type 3 Innate Lymphoid Cells
HIF Synonym(s)	ILC3s, Type 3 Innate Lymphoid Cells
HIF Classification	Innate lymphoid cells (ILCs)
Description	Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation				[1]

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	Innate lymphoid cell type 3Cderived interleukin-22 boosts the expression and production of lipocalin-2 (LCN-2) in intestinal epithelial cells (IECs) and resulting inhibiting growth of Escherichia coli.				[2]
Klebsiella pneumoniae (enterobacteria)			MIC01405
Description	ILC3s can produce IL-17 in response to Klebsiella pneumoniae infection.				[3]

References
1	Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation. Nat Commun. 2020 Apr 14;11(1):1794. doi: 10.1038/s41467-020-15612-2.
2	Innate lymphoid cell type 3-derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-B. J Biol Chem . 2019 Apr 12;294(15):6027-6041. doi: 10.1074/jbc.RA118.007290
3	Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.

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