Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01405)
MIC Name Klebsiella pneumoniae (enterobacteria)
MIC Synonyms Bacillus pneumoniae
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative or Respiratory; Utilize various carbohydrates
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 5682322
No. of Coding Genes 5514
No. of Non-Coding Genes 201
No. of Small Non-Coding Genes 201
No. of Gene Transcripts 5730
No. of Pseudogenes 15
No. of Base Pairs 5781501
Description Klebsiella pneumoniae is a facultative anaerobic, Gram-negative, non-motile, encapsulated, lactose-fermenting, rod-shaped bacterium. In the clinical setting, it is the most significant member of the genus Klebsiella of the Enterobacteriaceae. Although found in the normal flora of the mouth, skin and intestines, it can cause destructive changes to human and animal lungs if aspirated, specifically to the alveoli resulting in bloody, brownish or yellow colored jelly like sputum.
External Links Taxonomy ID
573
Genome Assembly ID
ASM36438v3
GOLD Organism ID
Go0005342
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Klebsiella pneumoniae was significantly higher in children in the autism spectrum disorder group compared with those in the TD group.. [1]
          Periodontal disease  [ICD-11: DA0C]
             Description Klebsiella pneumoniae together with other drug-resistant Enterobacteriacae has been previously reported to be present in oral cavities of patients with periodontal disease. [2]
          Pneumonia  [ICD-11: CA40]
             Description Certain strains of Klebsiella pneumoniae have the ability to outcompete others in the pulmonary environment and cause severe pneumonia. [3]
Host Genetic Factors (HGFs)
          MYD88
             HGF ID HGF2337 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MYD88 increased the abundance of Klebsiella pneumoniae. [4]
          C4B
             HGF ID HGF2348 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The low C4B-CN has been significantly associated with the decreased abundance of Klebsiella pneumoniae (p-value<0.05). [5]
          hsa-miR-292-5p
             HGF ID HGF2365 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-292-5p expression showed 1.07-fold up-regulation by Klesiella pneumonia infection. [6]
Host Immune Factors (HIFs)
          Interleukin 26
             HIF ID HIFM0146 HIF Info       Class Antimicrobial peptide (AMP)
             Description The recombinant human IL-26 inhibited the growth of gram-negative bacteria, such as Klebsiella pneumonia by direct bactericidal action and the median minimum inhibitory concentration values were in the range of 8.6 to 18.6 M. [7]
          CD73+CD80+ B cells
             HIF ID HIFC0159 HIF Info       Class B cells (BCs)
             Description CD73+CD80+ B cells can response to Klebsiella pneumoniae bacterial. [8]
          IgM memory B cells
             HIF ID HIFC0160 HIF Info       Class B cells (BCs)
             Description The presence of IgM memory B cells was associated with Klebsiella pneumoniae LPS glycan antigens. [8]
          C-X-C motif chemokine 1
             HIF ID HIFM0109 HIF Info       Class Cytokine (Cyt)
             Description There is a decreased survival in the CXCL1/ group and only 14.3% of mice survived after 15 days with Klebsiella pneumoniae infection(103 CFU/mouse). [9]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description In antibiotic-treated mice there was significantly less intrapulmonary IL-17A produced (p<0.01)in response to infection with Klebsiella pneumoniae. [10]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Neutrophils are critical to the host in clearance of ST258 Klebsiella pneumoniae. [11]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. [12]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Immunoblotting with bacterial lysates using sera from Tlr2 / Tlr4 / mice showed reduced IgG in Tlr2 / Tlr4 / sera that recognized antigens produced by fecal bacteria, symbiotic bacteria Eescherichia coli and Klebsiella pneumoniae, as well as the gram-negative enteric pathogens Salmonella enterica serovar Typhimurium (Salmonella) and Citrobacter rodentium. [13]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. [12]
          Type 3 Innate Lymphoid Cells
             HIF ID HIFC0009 HIF Info       Class Innate lymphoid cells (ILCs)
             Description ILC3s can produce IL-17 in response to Klebsiella pneumoniae infection. [11]
          CD14+ monocytes
             HIF ID HIFC0205 HIF Info       Class Monocytes (Mono)
             Description CD14+ monocytes response were associated with Klebsiella pneumoniae infection. [14]
          AKT Serine Kinase signaling pathway/AKT Threonine Kinase signaling pathway
             HIF ID HIFP0002 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Klebsiella pneumoniae is associated with Akt. [11]
          Extracellular signal-regulated kinase signaling pathway
             HIF ID HIFP0007 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Klebsiella pneumoniae is associated with ERK. [11]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Klebsiella pneumoniae is associated with NF-B. [11]
          Phosphoinositide 3 kinase signaling pathway
             HIF ID HIFP0033 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Klebsiella pneumoniae is associated with PI3K. [11]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Relative abundances of Klebsiella pneumoniae is associated with T cells response. [11]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Th17 cells can produce IL-17 in response to Klebsiella pneumoniae infection. [11]
Environmental Factor(s)
             Disbiome ID
      123
             gutMDisorder ID
      gm0380
             aBiofilm Organism
      Klebsiella pneumoniae
References
1 Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder. mSystems. 2019 Jan 29;4(1):e00321-18. doi: 10.1128/mSystems.00321-18. eCollection 2019 Jan-Feb.
2 The gut microbiome: scourge, sentinel or spectator. J Oral Microbiol. 2012;4. doi: 10.3402/jom.v4i0.9367. Epub 2012 Feb 21.
3 A Genomic Approach To Identify Klebsiella pneumoniae and Acinetobacter baumannii Strains with Enhanced Competitive Fitness in the Lungs during Multistrain Pneumonia. Infect Immun. 2019 May 21;87(6):e00871-18. doi: 10.1128/IAI.00871-18. Print 2019 Jun.
4 Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides.Version 2. Mucosal Immunol. 2012 Sep;5(5):501-12. doi: 10.1038/mi.2012.23. Epub 2012 Apr 11.
5 C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease.Clin Exp Immunol. 2017 Dec;190(3):394-405. doi: 10.1111/cei.13040. Epub 2017 Sep 25.
6 Whole blood-derived microRNA signatures in mice exposed to lipopolysaccharides. J Biomed Sci. 2012 Jul 31;19(1):69. doi: 10.1186/1423-0127-19-69.
7 IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses.PLoS Pathog. 2016 Jun 23;12(6):e1005624. doi: 10.1371/journal.ppat.1005624. eCollection 2016 Jun.
8 A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses.J Exp Med. 2018 Aug 6;215(8):2035-2053. doi: 10.1084/jem.20180977. Epub 2018 Jun 29.
9 Interleukin-8, CXCL1, and MicroRNA miR-146a Responses to Probiotic Escherichia coli Nissle 1917 and Enteropathogenic E. coli in Human Intestinal Epithelial T84 and Monocytic THP-1 Cells after Apical or Basolateral Infection.Infect Immun. 2016 Aug 19;84(9):2482-92. doi: 10.1128/IAI.00402-16. Print 2016 Sep.
10 The microbiota protects against respiratory infection via GM-CSF signaling. Nat Commun. 2017 Nov 15;8(1):1512. doi: 10.1038/s41467-017-01803-x.
11 Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.
12 IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway.Metab Brain Dis. 2017 Oct;32(5):1571-1583. doi: 10.1007/s11011-017-0040-2. Epub 2017 Jun 9.
13 Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.Immunity. 2016 Mar 15;44(3):647-658. doi: 10.1016/j.immuni.2016.02.006. Epub 2016 Mar 2.
14 M2b Monocytes Provoke Bacterial Pneumonia and Gut Bacteria-Associated Sepsis in Alcoholics.J Immunol. 2015 Dec 1;195(11):5169-77. doi: 10.4049/jimmunol.1501369. Epub 2015 Nov 2.

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